Sodium Citrate: The Role of Pre-Filled Syringes in Vascular Access Management

Pre-filled syringes containing sodium citrate are Class IIb medical devices used to maintain the patency of central venous catheters (CVCs). Thanks to their localized anticoagulant action, they offer a safe, effective, and standardized tool for vascular access management.

What Are Pre-Filled Syringes?

Pre-filled syringes are single-use medical devices that contain pre-measured, ready-to-use solutions. They provide several advantages in clinical practice: they reduce the risk of contamination, ensure accurate dosing, and simplify patient management.
These syringes are especially useful in both hospital and home care settings, where safety and efficiency are crucial.

Pre-Filled Sodium Citrate Syringes: Clinical Applications

Sodium citrate is an anticoagulant agent that works by chelating calcium in the blood, temporarily inhibiting the coagulation process. Pre-filled syringes containing sodium citrate are used as lock solutions in central venous catheters (CVCs), typically at the end of an infusion or dialysis session.

Their use helps prevent catheter lumen occlusion caused by clot formation, improving both safety and treatment continuity. The pre-filled format ensures precise dosing, reduces the risk of preparation errors, and promotes standardized procedures.

D.B.M. C-Lock 4%: A Ready-to-Use Lock Solution

A concrete example is D.B.M. C-Lock 4%, a sterile, single-use pre-filled syringe containing 4% trisodium citrate, manufactured by D.B.M. This Class IIb medical device is autoclave-sterilized and intended exclusively as a lock solution for central venous catheters.

D.B.M. C-Lock 4% is designed to fill the catheter lumen at the end of the infusion procedure, maintaining patency between uses through the anticoagulant action of citrate. The solution must not be injected systemically and should be aspirated and discarded before the next catheter use, in accordance with good clinical practice. The product is available in various sizes to match the internal volumes of different catheters.

Numantec: Integrated Biomedical Solutions

Numantec distributes a wide range of medical devices through the synergy of specialized companies in the healthcare sector. Its offering includes ready-to-use, reliable, and innovative solutions designed to meet the needs of daily clinical practice—from vascular access management to advanced infusion therapy.